rBCG -Recombinant Bacille Calmette – Guérin
It is a new possible vaccine for tuberculosis
Route: Intradermal
Antigen: Ag85b (in Purified protein derivative form)
Immune Response:
- including Ag85b-specific T cell expansion,
- enhanced cutaneous delayed-type hypersensitivity
- ↑ IFN-γ secretion,
- ↑ Ag85b-specific CD4+ TH1 cell responses
- ↑ Ag85b-specific CD8+ T cell responses
- ↑ effector and central memory Ag85b-specific T cells
- ↑ Ag85b-specific inhibitory T cell responses
All these immune effects leads to protection against air born TB infection.
Closely related other antigen / vaccine: Ag85a / MVA85A
[Reference: rBCG30 Safely Enhances Human TB Immunity ● JID 2008:198 (15 November): 1491-1501]
