rBCG -Recombinant Bacille Calmette – Guérin

It is a new possible vaccine for tuberculosis

Route: Intradermal

Antigen: Ag85b (in Purified protein derivative form)

Immune Response:

  • including Ag85b-specific T cell expansion,
  • enhanced cutaneous delayed-type hypersensitivity
  • ↑ IFN-γ secretion,
  • ↑ Ag85b-specific CD4+ TH1 cell responses
  • ↑ Ag85b-specific CD8+ T cell responses
  • ↑ effector and central memory Ag85b-specific T cells
  • ↑ Ag85b-specific inhibitory T cell responses

All these immune effects leads to protection against air born TB infection.


Closely related other antigen / vaccine: Ag85a / MVA85A



[Reference: rBCG30 Safely Enhances Human TB Immunity ● JID 2008:198 (15 November): 1491-1501]