Prostaglandins

PROSTAGLANDINS

1. Latanoprost ( 0.005% )
2. Bimatoprost ( 0.03% )
3. Travopost (0.04% )

Mechanism Of Action :

Stimulation of FP class of prostaglandin receptors in ciliary body & iris root

↓

Increase in activity of matrix metalloproteinase enzyme

↓

Remodeling of extra cellular matrix & widening of intermuscular spaces in the ciliary body

↓

Increase in uveo sclera outflow

↓

Reduce IOP

Duration of Action : 24 hours

Frequency : OD

SIDE EFFECTS :

1. Conjunctival hyperemia
2. Trichomegaly / hypertrichosis : increased eye lashes
3. Increased iris pigmentation
4. Foreign body sensation